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KMID : 1143420180110461552
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Public Health Weekly Report
2018 Volume.11 No. 46 p.1552 ~ p.1558
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Surveillance of Acute Flaccid Paralysis in the Republic of Korea, 2016-2017
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Lee Yong-Pyo
Yoon Young-Sil
Lee Deok-Young
Kim Joo-Ae
Choi Woo-Young
Kang Chun
Kim Hye-Jin
Lee June-Woo
Yoo Jung-Sik
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Abstract
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Acute flaccid paralysis (AFP) is described as the sudden onset of flaccid paralysis in one or more limbs in children and may be caused by poliovirus. AFP surveillance was undertaken by the World Health Organization (WHO) and since 1998, the Korea Centers for Disease Control and Prevention has conducted its own surveillance to monitor the progress of poliomyelitis eradication. One of the WHO indicators for polio elimination is strengthening of surveillance by maintaining the number of reported one or more non-polio AFP cases per 100,000 children aged less than 15 years. The AFP surveillance in the Republic of Korea was conducted through reporting and laboratory-based testing according to WHO recommendations. Conventional tube cell culture method was used for virus isolation and the isolates were identified by real-time reverse transcription-polymerase chain reaction (RT-PCR). For genotyping, seminested RT-PCR was used to amplify part of the viral protein (VP) 1 gene. Non-polio AFP rate per 100,000 children was 1.01 in 2016 and 1.00 in 2017. Seventy cases were reported from 12 provinces in 2016 and 68 cases were reported from 15 provinces in 2017. In 2016, 140 clinical specimens were collected from 70 patients; of these, 35 cases were positive for non-polio enterovirus (NPEV). In 2017, 136 clinical specimens were collected from 68 patients; of these, six cases were positive for NPEV. During 2016-2017, among the total of 138 cases, Guillain-Barre Syndrome (n=46, 36.8%) was the major leading cause of AFP. NPEV infection was diagnosed in 33 cases (47.1%) and the major genotype was Enterovirus (EV) 71 (n=20, 58.9%) during 2016-2017. This national surveillance of AFP will increase our understanding of the epidemiologic pattern and clinical manifestations associated with AFP in the Republic of Korea.
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KEYWORD
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Poliovirus, Enterovirus, Acute Flaccid Paralysis, Poliomyelitis, Non-polio enterovirus
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